The effect of the knock down of gut microbiota by antibiotics on parameters of body weight control and insulin sensitivity - ANTIBIOTICS study

niversiteit Maastricht0 sites56 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

March 31, 2014

Last Updated

last year

Study Type

Interventional

Sponsor

•BMI 25\-35 kg/m2, insulin resistant (HOMA\_IR \> 2\.2\), caucasian, male, 35\-70 years, impaired glucose tolerance (IGT: 2h plasma glucose during 75g OGTT 7\.8\-11\.1 mmol/l) and/or impaired fasting glucose (plasma glucose \>\= 5\.6\), stable body weight for at least three months (±3 kg).

•Known allergic reaction to vancomycin, teicoplanine, amoxicillin and other β\-lactam antibiotics (penicillins and cefalosporins) or related antibiotics. Diabetes mellitus, hearing disorders, cardiovascular disease, kidney disease, cancer, asthma or bronchitis, liver malfunction, major illness with a life expectancy \< 5 years, diseases affecting glucose tolerance (e.g. pheochromocytoma, Cushing\*s syndrome, acromegaly), use of antibiotics in the past 3 months, gastrointestinal disease, plans to lose weight and participation in organized sports activities for \>3 hours per week.
•The use of the following drugs: β\-blockers, lipid lowering\-drugs (e.g. PPAR γ or PPARa (fibrates) agonists), glucose\-lowering agents (including all sulfonylureas, biguanides, a\-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin), anti\-oxidants or chronic corticosteroids treatment (\> 7 consecutive days of treatment).