The effect of the knock down of gut microbiota by antibiotics on parameters of body weight control and insulin sensitivity - ANTIBIOTICS study

niversiteit Maastricht0 个研究点目标入组 56 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•BMI 25-35 kg/m2, insulin resistant (HOMA_IR > 2.2), caucasian, male, 35-70 years, impaired glucose tolerance (IGT: 2h plasma glucose during 75g OGTT 7.8-11.1 mmol/l) and/or impaired fasting glucose (plasma glucose >= 5.6), stable body weight for at least three months (±3 kg).

•Known allergic reaction to vancomycin, teicoplanine, amoxicillin and other β-lactam antibiotics (penicillins and cefalosporins) or related antibiotics. Diabetes mellitus, hearing disorders, cardiovascular disease, kidney disease, cancer, asthma or bronchitis, liver malfunction, major illness with a life expectancy < 5 years, diseases affecting glucose tolerance (e.g. pheochromocytoma, Cushing*s syndrome, acromegaly), use of antibiotics in the past 3 months, gastrointestinal disease, plans to lose weight and participation in organized sports activities for >3 hours per week.
•The use of the following drugs: β-blockers, lipid lowering-drugs (e.g. PPAR γ or PPARa (fibrates) agonists), glucose-lowering agents (including all sulfonylureas, biguanides, a-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin), anti-oxidants or chronic corticosteroids treatment (> 7 consecutive days of treatment).

发起方