Investigating the influence of the cold pressor test on cerebral blood flow regulatio
Withdrawn
- Conditions
- hersenaandoeningencerebrovascular disease
- Registration Number
- NL-OMON42979
- Lead Sponsor
- Geriatrie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
* Young adult group: aged 18-30 years
* Elderly group: aged *65 years
* Normal cognition, determined by MoCA Score * 26
* Able to provide informed consent
Exclusion Criteria
* Diagnosis of significant neurological or psychiatric diseases relevant for brain function or (cerebral) blood flow (e.g. stroke, dementias)
* History of brain surgery
* Diabetes mellitus, cardiovascular disease, hypertension, epilepsy
* Carotid artery stent or severe stenosis
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Cerebrovascular perfusion is examined at the level of the middle cerebral<br /><br>artery using TransCrandial Doppler (TCD, in cm/s) and cerebral cortex using<br /><br>near infrared spectroscopy (NIRS; concentration oxy/deoxy Hb in mmol/L).<br /><br>Furthermore, common carotid artery blood flow is measured with ultrasound<br /><br>(cm/s). These measurements will be performed before and across a 3-minute<br /><br>period of the CPT. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary parameters are ECG (3 lead), blood pressure (Finapres), and end-tidal<br /><br>CO2.</p><br>