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Clinical Trials/NCT00700700
NCT00700700
Terminated
Phase 4

Effects of Cardiac Resynchronization Therapy on Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure

Queen's University1 site in 1 country2 target enrollmentOctober 2008
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ConditionsCongestive Heart Failure

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Congestive Heart Failure
Sponsor
Queen's University
Enrollment
2
Locations
1
Primary Endpoint
Exercise endurance time
Status
Terminated
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the ventricular chambers of the heart. In some people, CRT improves exertional breathlessness and allows them to exercise for longer periods. However, to date, the mechanisms by which CRT improves symptoms and exercise tolerance is unknown. This study will use in-depth cardiopulmonary exercise testing and pulmonary function testing to explore these mechanisms in greater detail.

Registry
clinicaltrials.gov
Start Date
October 2008
End Date
June 2011
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • •clinically stable
  • •being considered for implantation of biventricular pacemaker for CRT
  • •LVEF \<35%
  • •QRS duration \>120 msec
  • •NYHA III-IV functional class
  • •optimized pharmacologic management of CHF
  • •no recent (\<1 month) episodes of decompensated CHF

Exclusion Criteria

  • •inability to perform cycle ergometry or comply with testing
  • •uncontrolled ischemic heart disease
  • •coronary revascularization within 3 months of study entry
  • •concurrent primary lung disease
  • •current use of ambulatory oxygen
  • •rhythm other than sinus
  • •dependency on pacemaker therapy as a consequence of bradyarrhythmias
  • •severe valvulopathy

Outcomes

Primary Outcomes

Exercise endurance time

Time Frame: 6 weeks

Study Sites (1)

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