To establish the correlation between level of serum NT PRO BNP and the severity of congenital heart disease in children

Not yet recruiting

Conditions: Other disorder of circulatory system,

Registration Number: CTRI/2023/08/056785

Lead Sponsor: Jawaharlal nehru medical college

Brief Summary: The Natriuretic peptides including BNP, ANP and pro BNP are secreted primarily by atrial and ventricular cardiomyocytes stretching, it has vasodilatory, natriuretic actions along with inhibition of RAAS and cardiac sympathetic activity. They are established most powerful markers for heart failure diagnosis and prognosis in across a spectrum of cardiovascular diseases.

The aim is to establish a reference range of NT-proBNP with the severity of shunt in Acyanotic congenital heart diseases. No Indian reference ranges/ cut off points have been established yet for the classification of severity of shunt (mild, moderate, severe) in CHDs. And since the quantity of shunt is not always perfectly determined by echocardiography and there is immense shortage of cardiologists in country especially Rural areas, we aimed at evaluating whether the serum level of BNP can be used as a screening marker for determining the amount and severity of left to right shunt in patients of VSD, ASD, PDA and other acyanotic conditions thus establish a cut off point for surgical intervention as well.

It would also serve as a good way to triage the patients for Echo cardiography, Determining the severity of the shunt can help prevent morbidities in patients of Congestive heart failure, Failure to thrive and Eisenmenger syndromes.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

All infant and children presenting with heart murmur, features of CCF, failure to thrive or history of recurrent respiratory infection, diagnosed to have ASD, VSD, PDA under echocardiography.

Exclusion Criteria

Children with: 1.
Septic shock, Thrombocytopenia 2.
Renal failure, Low GFR 3.
Active NEC, Active bleeding, Intra cranial Hemorrhage 4.
Heart failure due to cardiomyopathy, myocarditis, pericarditis or coronary artery disease.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To establish a relation between serum NT pro BNP levels & severity of shunt in patients of left to right shunt ASD VSD and PDA & other acyanotic conditions based on echocardiographic and hemodynamic evaluations	1 year hospital based study

Secondary Outcome Measures

Name	Time	Method
To determine cutoff point for surgical intervention in such patients	1 year hospital based study

Trial Locations

Locations (1): Dr KLE Prabhakar kore hospital and research centre
🇮🇳
Belgaum, KARNATAKA, India
Dr KLE Prabhakar kore hospital and research centre
🇮🇳Belgaum, KARNATAKA, India
Dr Ankit Anand
Principal investigator
8210983703
ankitanand120@gmail.com