Strength Training Effects on Clinical Outcomes of Patients with Compensated Cirrhosis
- Conditions
- Cirrhosis
- Registration Number
- RBR-9396d4
- Lead Sponsor
- Fundação Universidade de Caxias do Sul - FUCS/RS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Studied population will be of men and women with cirrhosis. To be a part of the sample, the patients will have to be in the inclusion criteria: age between 18 and 72 years, BMI 18.5-34.9, with no obesity or grade I (WHO). No force training prior to the study for 6 months, no current use of alcohol or tobacco for 6 months, if the patient is hypertensive it need to be controlled for inclusion, compensated cirrhosis Child A or B with histological documentation or through the association of laboratorial data ans image studies suggesting cirrhosis.
Exclusion criteria will be the following co-morbidities: decompensated diabetes, severe heart failure that prohibits exercise, periphereal amputations, chronic renal failure; clinical depression; muscular disease that physically impossibilits force training, decompensated cirrhosis, hence these patients cannot do heavy exercise. Regarding cirrhosis, exclusion criteria will be: decompensated cirrhosis, previous variceal bleeding without endoscopically confirmed erradication of esophageal varices, Child C, large varices, presence of ascitis.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Combined outcome of clinical complications (all-cause hospital admission, hepatic encephalopathy and all-cause death) measured though a brief interview each evaluation, measured dicotomically as yes-no
- Secondary Outcome Measures
Name Time Method Improvement of muscle quality and functional capacity after a 6-month intervention, measured through 6-minute walk test and muscle ultrasonography;<br>Improvement of liver-disease scores: Child-Pugh, MELD, MELD-Na in at least one point previous and after the intervention;<br>Improvement of mean leves of hemoglobin pre and post intervention;<br>Improvement of mean leves of sodium pre and post intervention;<br>Improvement of mean leves of INR pre and post intervention;<br>Improvement of mean leves of albumin pre and post intervention;<br>Improvement of mean leves of reacite C protein pre and post intervention;<br>Improvement of mean leves of total bilirubin pre and post intervention;<br>Improvement of mean leves of sarcopenia pre and post intervention measured through Computerized tomography;<br>Measurement of quality of life through questionaires SF-36, EICF and CLDQ validated for portuguese pre and post intervention;<br>Leves of force in femoral quadriceps pre and post intervention.