Energy Requirements in Patients With Ulcerative Colitis Undergoing Total Rectocolectomy and Ileoanal Anastomosis J-pouch
Trial Snapshot
- Phase
- Not Applicable
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Amount of resting energy expenditure (kcal/day)
Study Overview
Brief Summary
A prospective observational study to assess the energy needs of Ulcerative Colitis patients undergoing total proctocolectomy with ileoanal j-pouch anastomosis.
Detailed Description
Total proctocolectomy with creation of ileoanal j-pouch anastomosis is the gold-standard surgical procedure for familial polyposis, for ulcerative colitis unresponsive to medication and for colitis associated with dysplasia requiring total colectomy.
Patients postoperatively face difficulties in maintaining their physical condition and quality of life due to potential complications such as surgical, mechanical, inflammatory and functional disorders increasing the rates of malnutrition. Postoperative changes as regards anthropometric characteristics and nutritional status have not been fully elucidated.
Therefore, the need arises to calculate the energy needs of patients with ileoanal j-pouch anastomosis, given the lack of corresponding data and the possible differentiation of energy needs from a similar group of patients undergoing colorectal surgery.
Of particular interest is the body composition of ileoanal anastomosis patients, which has been studied very little ), and the extent to which their energy needs are met, given dietary restrictions both preoperatively and postoperatively.
It is therefore necessary to determine the energy needs, as well as the degree of their coverage by the diet, of UC patients undergoing proctocolectomy with creation of ileoanal j-pouch anastomosis.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with ulcerative colitis and planned proctocolectomy with ileoanal j-pouch anastomosis surgery or patients who are to undergo subtotal colectomy.
- •Age over 18 years.
- •Written informed consent to take part in the study.
- •Speaking ability in Greek or English.
- •Able to get tested fasted;
Exclusion Criteria
- •Age under 18 years.
- •Existence of pregnancy.
- •Inability to breathe inside the indirect calorimetry mask for the time required for the measurement.
- •Use of medications that may affect body metabolism will be evaluated individually (e.g. cortico-steroids etc.)
Outcomes
Primary Outcomes
Amount of resting energy expenditure (kcal/day)
Time Frame: Before surgery, 1 week postoperatively, 3 months postoperatively
To evaluate total energy needs of patients who undergo proctocolectomy with ileoanal j-pouch
Secondary Outcomes
- IBDQ(Before surgery and 1 week after Surgery)
- Resting energy expenditure change (kcal/day)(1 week postoperatively and 3 months postoperatively)
- Bristol stool form scale, min: type 1 (hard solid stools, better outcome) - max: type 7 (liquid stools, worst outcome)(Before surgery, 1 week postoperatively, 6 months after surgery)
- Post operative weight loss(1 week postoperatively, 3 months postoperatively)
- Post operative Energy intake.(1 week postoperatively, 3 months postoperatively)
Investigators
Dimitrios Karayiannis
Director, Department of Clinical Nutrition, Evaggelismos General Hospital, Athens
Evangelismos Hospital