Assessment of Energy Metabolism in Patients With Short Bowel Syndrome Using the Doubly Labeled Water Method
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Assessment of total energy expenditure using the doubly labeled water method
研究概览
简要总结
This study proposes to verify the total energy expenditure in patients with short bowel syndrome using the doubly labeled water method, as well as determining the rate of oxidation of nutrients, aiming to assist the management of nutritional therapy for these patients.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Short bowel syndrome: short bowel syndrome patients with gastrointestinal transit time less or equal 30 minutes.
- •Control group: patients with the same gender, presenting age and chronic diseases similar with volunteers from the group with short bowel syndrome.
排除标准
- •Short bowel syndrome: time of bowel resection surgery less than 1 year.
结局指标
主要结局
Assessment of total energy expenditure using the doubly labeled water method
时间窗: 14 days
After the determination of resting energy expenditure (REE), each volunteer will receive a dose of doubly labeled water (2H2 18O). A basal urine sample is collected before the intake dose and samples taken on days 1, 2, 3, 7, 12, 13, 14, thereafter. Urine samples will be analyzed by mass spectrometry (Hydra System, HIP 20-20, Europa Scientific, Cheshire, UK) in the Mass Spectrometry Laboratory of the Faculty of Medicine of Ribeirão Preto.
次要结局
- Resting energy expenditure (REE) and body composition measurements by indirect calorimetry and electrical bioimpedance, respectively.(After 12 hours of overnight fasting)
- Physical activity assessment(14 days)
研究者
Julio Sergio Marchini
Full Professor of Internal Medicine Department at Ribeirão Preto Medical School
University of Sao Paulo