Validation of a Multitask Deep Learning System at Spine Metastasis CT

• Conditions: To Evaluate Performance of the DLS
• Interventions: Diagnostic Test: Deep Learning System

• Registration Number: NCT05156567
• Lead Sponsor: Shanghai 6th People's Hospital

Brief Summary

The multitask deep learning system (DLS) with five algorithms detecting five quantitative factors of Spinal Instability Neoplastic Score (SINS) was developed. Radiologists and oncologists from multicenter will be recruited to read the CT scans in picture archiving and communication system (PACS) independently, comparing with the DLS. One month after reading the CT scans in PACS, the participants will also asked to perform a web-based test in the DLS website using the same CT scans. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the DLS were calculated with professional graders as the reference standard.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-12-12
• Study First Submitted QC: 2021-12-12
• Study First Posted: 2021-12-14
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-31
• Last Update Posted: 2022-06-01
• Study Start: 2022-07-01
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 420

Inclusion Criteria

1. pathology-proven diagnosis of solid tumor;
2. spinal CT scan indicating spinal metastasis with at least one lesion;
3. no previous surgery for spinal metastasis

Exclusion Criteria

1. spinal CT scans with no sagittal reconstruction;
2. the radiologist considered that the quality of CT image was unqualified.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
DLS	Deep Learning System	-

Primary Outcome Measures

Name	Time	Method
AUC	1 months	Area under the receiver operating characteristic curve (AUC) of spinal instability detection

Secondary Outcome Measures

Name	Time	Method
sensitivity	1 months	sensitivity of spinal instability detection
specificity	1 months	specificity of spinal instability detection

Trial Locations

Locations (1)

Shanghai Sixth People's Hospital; 🇨🇳 Shanghai, China