The COVid cohORT on Smell loss
Recruiting
- Conditions
- COVID-19
- Registration Number
- NL-OMON28538
- Lead Sponsor
- WUR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 75
Inclusion Criteria
Aged between 18-60 years, as olfactory function typically declines after the age of 60 years; recent Covid-19 infection (< 3 months), confirmed with a positive PCR-test, performed at a hospital or by the GGD; persistent self-reported smell loss (> 1 month); willing to comply with the study procedures; Dutch speaking; having given informed consent
Exclusion Criteria
Having any pre-existing olfactory or gustatory disorders (i.e. more than 2 weeks prior to the Covid-infection)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Objective assessment of parosmia by means of the SSParoT; objective olfactory function by means of Sniffin’ Sticks; objective gustatory function by means of Taste Strips. For the neuroimaging part: activation of brain regions in response to odor administration; activation of functional connectivity networks in the brain in response to odor administration; volume of the olfactory bulbs; total brain volume and volume of olfactory-related brain regions
- Secondary Outcome Measures
Name Time Method Self-reported smell, taste, parosmia and trigeminal sensations; scores on home-use-test (https://riech-check.de/); eating behavior, as measured by the Appetite, Hunger and Sensory Perception questionnaire and VAS ratings on food enjoyment and appetite; quality of life, as measured by the Questionnaire of Olfactory Disorders