COVORTS study: the COVid cohORT on Smell loss

Recruiting

Recruitment & Eligibility

Inclusion Criteria

patients (18-60 years) with persistent (> 1month) self-reported smell loss
within three months after COVID-diagnosis.

For the neuroimaging substudy: patients (18-60 years) with persistent (>
1month) self-reported smell loss after COVID-diagnosis.

Exclusion Criteria

any pre-existing olfactory or gustatory disorders ( i.e. more than 2 weeks
prior to the covid-infection)

for the neuroimaging subpart:
pregnant, or intending to become pregnant during the course of the study
Having a contra-indication to MRI scanning

Primary Outcome Measures

Name	Time	Method
<p>Objective assessment of parosmia by means of the SSParoT;<br /><br>Objective olfactory function by means of Sniffin*Sticks;<br /><br>Objective gustatory function by means of Taste Strips.<br /><br>With this, we will assess longterm prevalence of parosmia within the cohort, as<br /><br>well as describe the smell and taste ability of patients. Mean and median time<br /><br>interval to clinical improvement (recovery) will be reported as measure of<br /><br>duration of parosmia.<br /><br><br /><br>For the neuroimaging part: differences in olfactory bulb volume, differences in<br /><br>volume of olfactory-related brain regions, and differences in activation of<br /><br>brain regions upon odor stimuli between patients with smell loss (i.e. anosmia<br /><br>and hyposmia) and parosmia will be analyzed. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To assess the longterm prevalence of anosmia, hyposmia, and taste loss.<br /><br>To measure smell and taste function subjectively longitudinally in a cohort of<br /><br>Covid-19 patients with self-reported smell loss.<br /><br>To assess the impact of smell/taste changes on eating behavior and quality of<br /><br>life.<br /><br><br /><br>To assess changes over time in olfactory bulb volume, volume of<br /><br>olfactory-related brain regions over time, and functional responses in a subset<br /><br>of Covid-19 patients </p><br>