Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients
Not Applicable
- Conditions
- Postoperative Complications
- Interventions
- Other: Hyperinsulinemic Normoglycemic Clamp
- Registration Number
- NCT01001273
- Lead Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Brief Summary
This study proposes a simple and safe way of lowering this complicate rate, while improving graft recovering and protecting the graft as it recovers from the transplant. The investigators hypothesize that by maintaining a tight glucose control via a glucose-insulin clamp during surgery and 72 hours post-operatively the investigators will be able to lower the complication rate by 50%.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Male or female patient over 18 years of age
- Patient is about to receive a pancreas or a simultaneous pancreas/kidney transplant
- Able to give written informed consent prior to any study specific procedure
Exclusion Criteria
- Multi-organ transplant other than kidney transplant
- No central venous access available to deliver the D20W solution
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Study Group Hyperinsulinemic Normoglycemic Clamp Hyperinsulinemic Normoglycemic Clamp will be started at the time of surgery (before incision) and will be continue for 3 days.
- Primary Outcome Measures
Name Time Method The number of post-transplants all complications up to 30 days (Clavien grading). 30 days post-operative
- Secondary Outcome Measures
Name Time Method The length of hospital stay (days) Length of hospital stay (day 1 until discharge) The number of 30 days post-transplant serious medical complication (Clavien grade 3, 4) 30 days post-op
Trial Locations
- Locations (1)
Hospital Royal Victoria
🇨🇦Montreal, Quebec, Canada