Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

Phase 2

Withdrawn

• Conditions: Dysfunctional Labor
• Interventions: Drug: Propranolol; Other: IV Placebo

• Registration Number: NCT00315913
• Lead Sponsor: University of California, Irvine

Brief Summary

The purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. The endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

Detailed Description

This trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. Due to stringent inclution and exclusion criteria and low enrollment the study was closed.

Study Timeline

• Study Start: 2004-01
• Study First Submitted: 2006-04-17
• Study First Submitted QC: 2006-04-17
• Study First Posted: 2006-04-19
• Primary Completion: 2008-03
• Study Completion: 2008-03
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-26
• Last Update Posted: 2019-02-27

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• Must be term pregnancy (> 37 weeks)
• Vertex presentation
• Active labor (4-5 centimeters dilated)

Exclusion Criteria

• Heart disease
• Diabetes
• Currently taking propranolol
• Contraindications to labor or vaginal delivery
• Multiple gestations
• Preterm
• Chorioamnionitis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IV Propranolol	Propranolol	IV dose propranolol
IV Placebo	IV Placebo	IV Placebo of saline solution equal to propranolol in volume

Trial Locations

Locations (1)

Long Beach Memorial Medical Center; 🇺🇸 Long Beach, California, United States