Impact of coeliac plexus neurolysis on pain and quality of life in patients with pancreatic cancer

Not Applicable

• Conditions: Pancreatic cancer; Cancer - Pancreatic; Anaesthesiology - Pain management

• Registration Number: ACTRN12623001005640
• Lead Sponsor: Royal Brisbane & Women's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-15
• Last Update Posted: 26 September 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

•All patients with a confirmed clinical diagnosis of pancreatic cancer
•Medical documentation and treatment of abdominal pain as established by need for regular opiate use
• 18 years and over

Exclusion Criteria

•Advanced disease state that is impacting on capacity to consent
•Patients who have painless PC not requiring regular opiate medication to treat pain,
•Elevated INR > 1.5
•Decompensated cardiac failure (NYHA class IV)
•Decompensated liver failure (Child-Pugh score B/C)
•Severe hypotension (sBP<85mmHg)
•Currently pregnant

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Pain scores from T1 (Day of procedure, EUS-CPN) to T3 (1 month post EUS-CPN procedure).<br>* Likert pain score out of 10, This is recorded in a pain diary, morning and night for 3 months. <br><br>[ T1 (Day of EUS-CPN procedure, before procedure) - T3 (1-month post EUS-CPN procedure, anytime of the day as this is a clinic appointment at any time of the day)];Change in Quality-of-life (QOL) survey data from T1 (Day of procedure, EUS-CPN) to T1 -T3 (1 month post EUS-CPN procedure). <br>* PAN-26 <br>[ Change in QOL domain scores from T1 (Day of procedure, EUS-CPN) to T3 (1 month post EUS-CPN procedure).];Change in Quality-of-life (QOL) survey data from T1 (Day of procedure, EUS-CPN) to T1 -T3 (1 month post EUS-CPN procedure). <br>*EORTC-QLQ C30. [ Change in QOL domain scores from T1 (Day of procedure, EUS-CPN) to T3 (1 month post EUS-CPN procedure). This is a composite outcome.]