Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Completed

• Conditions: Head and Neck Cancer

• Registration Number: NCT00899340
• Lead Sponsor: Vanderbilt-Ingram Cancer Center

Brief Summary

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.

PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.

Detailed Description

OBJECTIVES:

* To investigate if some of the differences in gene expression are also reflected at the protein level.

* To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.

* To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.

Study Timeline

• Study Start: 2006-05
• Primary Completion: 2008-03
• Study Completion: 2008-03
• Study First Submitted: 2009-05-09
• Study First Submitted QC: 2009-05-09
• Study First Posted: 2009-05-12
• Status Verified: 2013-03
• Last Update Submitted: 2013-03-29
• Last Update Posted: 2013-04-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Diagnosis of squamous cell carcinoma of the oropharynx
• Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and Vanderbilt Pathology archives

Exclusion Criteria

• Not specified

PRIOR CONCURRENT THERAPY:

• Not specified

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of biomarkers for early detection or recurrence surveillance	after 7 months of tissue collection
Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx	after 7months of tissue collection