Catheter ABlation of Atrial fibrillation versus atrioventricular nodal ablation with CondUction System pacing in persistent atrial fibrillation and heart failure (ABACUS)

niversity Hospital of Geneva0 个研究点目标入组 220 人开始时间: 2024年8月5日最近更新: 2024年8月19日

试验速览

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•1. Persistent AF with symptomatic HF despite medical therapy, considered to be suitable for AF ablation, with at most one previous PVI procedure
•2. At least one prior hospital admission, or emergency room / HF clinic visit for HF in the past 2 years, with NT-pro-BNP >1000 pg/ml or BNP >250 pg/ml measured at any timepoint during this interval
•3. Previous or current rate or rhythm control drug therapy
•4. Considered eligible for CSP implantation as an alternative to AF ablation
•5. Age > or = 60 years

•1. NYHA Class IV and systolic blood pressure =80 mmHg despite optimized therapy
•2. Life expectancy <2 years
•3. Need for major surgical intervention
•4. Myocardial infarction, stroke or percutaneous coronary intervention within the previous 3 months
•5. Previously implanted or planned implantation of CRT device or pacemaker. Implantable cardioverter defibrillator (ICD) implantation without a pacing indication is acceptable.
•6. Participation in another controlled trial
•7. Inability to sign an informed consent form

发起方

niversity Hospital of Geneva