Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression
Not Applicable
- Conditions
- Chronic Depression
- Interventions
- Behavioral: Cognitive Behavioural Analysis System of Psychotherapy
- Registration Number
- NCT00596986
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission)
- HAMD-24>20
Exclusion Criteria
- Concurrent Psychotherapy or Psychopharmacotherapy
- Previous Non-Response to Duloxetine
- Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode
- Serious Psychiatric comorbidity
- Serious Neurologic comorbidity
- Contraindications to Duloxetine
- Contraindications to fMRI
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description AD Duloxetine Antidepressant Duloxetine PT Cognitive Behavioural Analysis System of Psychotherapy Psychotherapy (CBASP) - Cognitive Behavioural Analysis System of Psychotherapy
- Primary Outcome Measures
Name Time Method Neuroimaging Data (fMRI) Before and After Therapy
- Secondary Outcome Measures
Name Time Method HAMD Weekly Salivary Cortisol Before and After Therapy
Trial Locations
- Locations (1)
Charité Universitätsmedizin
🇩🇪Berlin, Germany