Effect of simvastatin withdrawal on ocular endothelial function - Simvastatin Flicker

Medical University of Vienna0 个研究点目标入组 20 人开始时间: 2015年3月19日最近更新: 2018年9月10日

试验速览

暂无简介。

•- Informed consent for participation
•- Men and women aged between 18 and 45 years, non-smokers
•- Body mass index between 15th and 85th percentile
•- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
•- Normal laboratory values unless the investigator considers an abnormality
•to be clinically irrelevant
•- Systolic blood pressure < 140 mmHg, diastolic blood pressure < 90 mmHg
•- Normal ophthalmic findings, ametropia less than 6 diopters
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 20
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- History or presence of ocular disease
•- Ametropy = 6 dpt
•- Previous or current treatment with statins
•- Treatment with any drug in the 3 weeks preceding the first study day
•- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
•- Participation in a clinical trial in the 3 weeks preceding the first study day
•- Blood donation during the 3 weeks preceding the first study day
•- History of family history of epilepsy
•- History or presence of myopathy, renal failure or elevation of creatine kinase (CK)
•- above normal levels
•- History or presence of hepatic dysfuncion, including increase of liver enzymes
•- Abuse of alcoholic beverages
•- Pregnancy

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