Effectiveness of ketogenic diet on excessive daytime sleepiness in adults with narcolepsy type 1: a proof of concept study

Recruiting

• Conditions: low-carbohydrate high-fat; 10040998

• Registration Number: NL-OMON51890
• Lead Sponsor: Stichting Epilepsie Instellingen Nederland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

Diagnosis of narcolepsy type 1 as classified by the International
Classification of Sleep Disorders-3 (ICSD-3)
18 years or older
Motivated to commit to the diet

Exclusion Criteria

Underweight (BMI < 18.5)
Diabetes Mellitus
Thyroid disfunction
mental / psychiatric difficulties
use of y-hydroxybutyrate
pregnant or lactating women or women trying to conceive
excessive drug or alcohol use

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint of the study is sleep latency on the Maintenance of<br /><br>Wakefulness Test (MWT).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are sustained attention using the Sustained Attention to<br /><br>Response Task (SART), the self-reported EDS. mental wellbeing, sleep quality,<br /><br>ADHD symptoms, cataplexy, and feasibility of the ketogenic diet.</p><br>