Inferior Vena Cava Diameter Dependent Colloid Challenge Versus Routine Crystalloid Strategy Transurethral Resection Prostate

Not Applicable

Completed

• Conditions: Volume Overload
• Interventions: Other: Ultrasound-guided Inferior vena cava diameter dependent colloid challenge versus routine crystalloid strategy Fluid replacement

• Registration Number: NCT04131361
• Lead Sponsor: Mansoura University

Brief Summary

Background: Intravenous fluid replacement during transurethral resection of the prostate is still unclear. Ultrasonography of the inferior vena cava (IVC) has been recently used to assess the volume status and predict fluid responsiveness. In this double-blind, randomized controlled study, we will assess the IVC at baseline and at subsequent time points after spinal anesthesia, and according to IVC diameter will give the replacement challenge colloid. Potential problems during TURP are mostly due to either fluid overload or bleeding: Intraoperative TURP syndrome, Hemorrhage, Myocardial ischemia, Hypothermia, Prostatic capsular perforation, Bladder or urethral perforation. Postoperative TURP syndrome, myocardial ischemia/infarction, Postoperative cognitive impairment. Study Hypothesis: Strict colloid volume optimization using US-guided IVC diameter calculation aiming decrease the total IV fluid volume and accommodate the transurethral inevitable absorption of currently used irrigation crystalloid fluid (Nacl0.9%) that accidentally absorbed and change it from a circulatory overload to a complementary part of the replacement IV fluids preventing fluid overload and TURP syndrome. Aim of the work: To reduce Intraoperative and postoperative fluid overload during TURP surgery with hemodynamic stability relaying up on US-guided IVC diameter dependent Strict IV Colloid replacement volume optimization. Methods: A prospective randomized controlled trial on ASAI-III male patient aged 40-80 years old subjected to transurethral endoscopic resection of the prostate (TURP) surgery. Then patients will be divided into 2 groups according to the IV infusion fluid type as follow: Crystalloid -control group: (preload plus continuous IO Ringer acetate crystalloid 4/2/1 rule infusion) according to the usual 4/2/1 rule. Not guided by IVC diameter but IVC diameter will be calculated using the US and recorded at baseline just after spinal anesthesia and then every 30 minutes till the end of surgery. Loop Diuretic (Furosemide) will be given according to the maximum diameter of the IVC as follow; 10mg if IVC\>2.5Cm. Colloid- study group: (preload plus colloid challenge only); Fluid challenge boluses of 250 mL (over 5 minutes using a pressurizer) 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (voluven®) if the IVC\<1.7(higher limit of normal) will be given guided by IVC diameter at baseline just after spinal anesthesia and then every 30 minutes till the end of surgery.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2019-10-12
• Study First Submitted QC: 2019-10-17
• Study First Posted: 2019-10-18
• Study Start: 2022-10-01
• Primary Completion: 2022-12-25
• Study Completion: 2022-12-30
• Status Verified: 2023-06
• Last Update Submitted: 2023-06-08
• Last Update Posted: 2023-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 34

Inclusion Criteria

• Inclusion Criteria:

  • Patients subjected to transurethral resection of prostate TURP.
  • ASA I&II
  • Age 40-80years old. prostate size 45-100
  • Surgical procedure: laser and Bipolar TURP using saline 0,9% irrigation.

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Exclusion Criteria

• Height <150 cm.
  • Weight <60 kg.
  • Body mass index ≥45 kg/m2.
  • Contraindications to spinal anesthesia (increased intracranial pressure or local skin infection).
  • Uncontrolled; Diabetes mellitus, cardiovascular failure, cerebrovascular uncontrolled deficite, or other renal disease.
  • Hemoglobin <10 gm/dL.
  • International Normalized Ratio >1.4
  • Platelet count <100,000 /mm3.
  • Preoperative serum creatinine >1.5 mg/dL

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Crystalloid -control group:	Ultrasound-guided Inferior vena cava diameter dependent colloid challenge versus routine crystalloid strategy Fluid replacement	-
Colloid- study group:	Ultrasound-guided Inferior vena cava diameter dependent colloid challenge versus routine crystalloid strategy Fluid replacement	-

Primary Outcome Measures

Name	Time	Method
total iv fluids	just after end of surgery

Secondary Outcome Measures

Name	Time	Method
Incidence of bradycardia	serial during surgery
serum Na at end of surgery	just after end of surgery
serum K at end of surgery	just after end of surgery
Incidence of hypo-tension	serial during surgery
ximum and minimum IVC diameter	serial during surgery
IVC-CI	serial during surgery

Trial Locations

Locations (1)

Anesthesia Department; 🇪🇬 Mansoura, Dakahlia, Egypt