Transcranial Electrical Stimulation in Multiple Sclerosis
- Conditions
- Multiple Sclerosis
- Registration Number
- NCT06966128
- Lead Sponsor
- Universitair Ziekenhuis Brussel
- Brief Summary
First the investigators will examine if the blood flow in the brain is different in patients with Multiple Sclerosis compared to healthy volunteers.
HOW? - The blood flow of the subjects is imaged by use of a special MRI-technique.
Secondly, the investigators will examine if the blood flow can determine disease progression.
HOW?
- Multiple Sclerosis patients are asked for a follow-up visit after two years.
The main goal is to understand the effect of transcranial Direct Current Stimulation (tDCS) on the cerebral blood flow.
* Does tDCS result in a different blood flow, in which brain regions? Is there a difference between healthy volunteers and Multiple Sclerosis patients? HOW?
* Participants get two session of tDCS. Before, during and after stimulation MRI scans are performed.
- Detailed Description
Comparison of CBF between healthy volunteers and MS patients:
- Arterial spin labelling (ASL) is used to investigate cerebral blood flow in patients with MS and healthy volunteers.
The effect of transcranial direct current stimulation (tDCS) on cerebral blood flow:
* ASL scans are performed before-, during-, and after tDCS
* Each subject will receive active and sham tDCS (seperated by at least two days) (cross-over design).
Follow-up visit:
* After two years, patients with MS are re-invited.
* This visit will include a new neuropsychological evaluation, blood sampling and additional brain scans.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Cerebral blood flow (CBF) Baseline, visit 2, and after two years Measure of brain perfusion.
CBF is measured at baseline and after two years. Additionally, the investigators will measure CBF before-, during-, and after tDCS.
- Secondary Outcome Measures
Name Time Method Symbol Digit Modalities Test (SDMT) Baseline and after 2 years Measure of information processing speed
California Verbal Learning Test (CVLT-II) Baseline and after 2 years Measure of verbal memory
Controlled Oral Word Association Test (COWAT) Baseline and after 2 years Measure of verbal fluency
Brief visuospatial Memory Test (BVMT-R) Baseline and after 2 years Measure of spatial memory
Fatigue Scale for Motor and Cognitive Function (FSMC) Baseline and after 2 years Measure of fatigue
Beck's depression inventory (BDI) Baseline and after 2 years Measure of depression
MRI T1 scan Baseline and after 2 years Cortical volume, volumes of white matter and deep grey matter
MRI T2 FLAIR scan Baseline and after 2 years Lesion load, lesion volume