TCTR20181119002Terminated未知
The role of childhood adversity in cortisol dysregulation in depressed and non-depressed methamphetamine users with and without history of suicide
none0 sites195 target enrollmentStarted: November 19, 2018Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Terminated
- Sponsor
- Enrollment
- 195
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 Years to 65 Years (—)
- Sex
- All
Inclusion Criteria
- •(a) age of 18 to 65 years; (b) a history of at least two years of continuous consumption of methamphetamine by a vapor inhalation model about 0.5 to 1 g/day; (c) a diagnosis of drug dependence and MDD based on DSM-5 criteria and history of suicide attempt in the past or the existence of suicidal ideation in the last 12 months; (d) being in the abstinence phase for at least six and not more than 12 months and the presence of PAWS in the depressed group; (e) the history of suicide attempt at least once and at most three times; (f) body mass index (BMI) between 18 and 35 kg; and (g) lack of suicide attempts and suicidal ideation in the control group.
Exclusion Criteria
- •(a) history of seizure, head trauma, endocrine disruptions, cardiovascular disease or other specific chronic diseases; (b) treatment in the last 6 months with antidepressants, neuroleptics, sedatives, glucocorticoids, appetite suppressants, estrogens, dopamine medications; (c) Experience of any extraordinary stress at present; and (d) pregnancy, hormone intake, or any cortisol simulants or suppressants. Money was paid to people for their contributions.
Investigators
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