The effect of N-acetyl cysteine and vitamin C on kidney in patients undergoing open heart surgery.

Not Applicable

• Conditions: Condition 1: Renal failure. Condition 2: coronary vessel disease.; Acute renal failure; Atherosclerosis heart disease

• Registration Number: IRCT2014072815102N4
• Lead Sponsor: Vice chancellor for research affairs, Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

age above 70 years old; Renal failure; Serum Cr level above 1.4 mg/dl; Heart ejection fraction of below 35%; Concomitant valve surgery with bypass surgery; History of previous coronary artery surgeries; Diabetes under treatment with oral agents or insulin.
Exclusion criteria: The emergency cardiac bypass surgery; History of heart transplantation; Acute renal failure; Serum Cr level higher than 4.5 mg/dl; History of renal transplantation; N-acetyl cysteine consumption in the last 5 days prior to the operation.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of N-acetyl cysteine on kidney. Timepoint: the 1st, 2nd and 3rd day after surgery. Method of measurement: Serum creatinine level.;The effect of N-acetyl cysteine and vitamin C on kidney. Timepoint: the 1st, 2nd and 3rd day after surgery. Method of measurement: Serum creatinine levels.

Secondary Outcome Measures

Name	Time	Method
Blood pressure. Timepoint: before surgery. Method of measurement: the peripheral blood pressure was measured with sphygmomanometer.;Number of grafts. Timepoint: after surgery. Method of measurement: review of operation note.