Sarcopenia and exercise in seniors

Not Applicable

Completed

• Conditions: Sarcopenia; Musculoskeletal Diseases

• Registration Number: ISRCTN39600964
• Lead Sponsor: Geneva University Hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-01
• Study Completion: 2020-03-31
• Last Update Posted: 5 August 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 196

Inclusion Criteria

1. Age =65 years (no upper age limit)
2. Short Physical Performance Battery (SPPB) score between 3 and 9, inclusive
3. Presence of low muscle mass according to the Baumgartner definition
4. Able to complete the 400 m walk test within 15 minutes without sitting or the help of another person, or the use of a walker
5. Willingness to give informed consent, to be randomized to one of the two study groups, and comply with all study requirements

Exclusion Criteria

People are excluded from participation in the study for any condition likely to affect the safety of the intervention and/or limit lifespan, or factors that may limit adherence to intervention or affect conduct of the trial (e.g., physical limitations should not be clearly attributable to the direct effect of a specific disease). In particular, exclusion criteria applied are:
1. Resides in a nursing home or is hospitalized
2. Diagnosis of dementia or score <21 on the MMSE
3. Serious neurological, neuromuscular or orthopaedic condition (e.g.,Parkinson's disease)
4. Serious cardiovascular or pulmonary condition (including myocardial infarction in previous 6 months) or development of chest pain or severe shortness of breath on the 400 m walk test
5. Participation in a supervised music-based multitask exercise program in the past 12 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physical performance, measured with the Short Physical Performance Battery (SPPB) score at baseline, 6 and 12 months

Secondary Outcome Measures

Name	Time	Method
1. Skeletal muscle health (including muscle strength and muscle mass, assessed by dynamometry and dual-energy X-ray absorptiometry, respectively) at baseline, 6 and 12 months<br>2. Sarcopenia status according to cut-off points for sarcopenia at baseline, 6 and 12 months<br>3. Other physical performances (including gait speed, five times sit-to-stand test time and Timed Up & Go tests) at baseline, 6 and 12 months<br>4. Balance (including simplified Tinetti test) measured at baseline, 6 and 12 months<br>5. Cognitive performance, measured with a comprehensive neuropsychological battery assessing different aspects of executive functioning at baseline, 6 and 12 months<br>6. Incidence of falls and injurious falls, measured with prospective daily recording using calendars at baseline, 6 and 12 months<br>7. Mobility disability (including 400m walk test) at baseline, 6 and 12 months<br>8. Quality of life (including SF-36, SarQol) at baseline, 6 and 12 months