comparison of thoracic epidural versus conventional opioids for measuring ScvO2 in patients undergoing coronary artery bypass grafting
Not Applicable
- Conditions
- Health Condition 1: I257- Atherosclerosis of coronary arterybypass graft(s) and coronary artery of transplanted heart with angina pectoris
- Registration Number
- CTRI/2022/07/043717
- Lead Sponsor
- Dr DY Patil medical college and research center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients undergoing coronary artery bypass grafting â?? ejection fraction > 30%.
2.American Society of Anesthesiology (ASA) grade II, III
3.INR < 1.5
Exclusion Criteria
1)Unwilling patients
2)Patients with deranged left ventricular function
3) Patients with any neurological and psychiatric disorders.
4) Patients with any contra indications for neuraxial blockade.
5) Patients posted for emergency procedures.
6) History of allergy to any of the drugs being used under study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To find out the effectiveness of High Thoracic Epidural Anaesthesia (HTEA) in obtunding the surgical stress response in patients undergoing coronary artery bypass grafting (CABG) and thereby improving tissue perfusion as measured by mixed venous oxygen saturation.Timepoint: To find out the effectiveness of High Thoracic Epidural Anaesthesia (HTEA) in obtunding the surgical stress response in patients undergoing coronary artery bypass grafting (CABG) and thereby improving tissue perfusion as measured by mixed venous oxygen saturation which we will measure as- <br/ ><br>baseline, <br/ ><br>half hour after epidural,on pump, <br/ ><br>post pump, <br/ ><br>postop 24 hours
- Secondary Outcome Measures
Name Time Method The following points will be considered during the study â?? <br/ ><br>â?¢Changes in tissue perfusion by mixed venous saturation. <br/ ><br>â?¢Lactate levels. <br/ ><br>â?¢Haemodynamic changes in Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP). <br/ ><br>â?¢Arterial blood gas (ABG) analysis. <br/ ><br>â?¢Pulmonary arterial wedge pressure. <br/ ><br>â?¢Haematocrit. <br/ ><br>â?¢Central venous pressure <br/ ><br>â?¢Amount of blood transfused and intravenous fluids. <br/ ><br>Timepoint: baseline, half hour after epidural, on pump, post bypass, post operatively