IRCT20200415047080N1招募中3 期
A prospective randomized controlled trial to compare recombinant tissue-type plasminogen activator (rt-PA) and standard treatmentin in patients with ARDS induced by COVID-19
适应症
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 70 years（—）
- 性别
- All
入选标准
- •A person with laboratory confirmation of COVID-19 infection
- •clinical and radiological confirmation of ARDS
- •The confirm case of covid-19 in patients with ARDS (PaO2/FiO2a = 300 or sat o2= 315 mmHg (with PEEP or CPAP = 5 cmH2O, or non-ventilated)
排除标准
- •Bleeding tendency
- •Coagulopathy (INR>1.5)
- •Thrombocytopenia (plt< 50000)
- •Previous hypersensitivity to Alteplase
- •Active internal bleeding
- •Severe uncontrolled hypertension
- •Severe renal disease (GFR<50 ml/min)
- •History of recent stroke
- •Hemoptysis at admission
- •Presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last 2 years
- •Moderate to severe liver failure (Childs-Pugh Score > 12)
- •Major trauma in the prior 30 days
- •Moribund patient not expected to survive the next 24 hours.
- •No consent/inability to obtain consent
研究者
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