IRCT20200415047080N1
Recruiting
Phase 3
A prospective randomized controlled trial to compare recombinant tissue-type plasminogen activator (rt-PA) and standard treatmentin in patients with ARDS induced by COVID-19
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- COVID-19.
- Sponsor
- Tehran University of Medical Sciences
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A person with laboratory confirmation of COVID\-19 infection
- •clinical and radiological confirmation of ARDS
- •The confirm case of covid\-19 in patients with ARDS (PaO2/FiO2a \= 300 or sat o2\= 315 mmHg (with PEEP or CPAP \= 5 cmH2O, or non\-ventilated)
Exclusion Criteria
- •Bleeding tendency
- •Coagulopathy (INR\>1\.5\)
- •Thrombocytopenia (plt\< 50000\)
- •Previous hypersensitivity to Alteplase
- •Active internal bleeding
- •Severe uncontrolled hypertension
- •Severe renal disease (GFR\<50 ml/min)
- •History of recent stroke
- •Hemoptysis at admission
- •Presence of any active malignancy (other than non\-melanoma skin cancer) that required treatment within the last 2 years
Outcomes
Primary Outcomes
Not specified
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