The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels

Not Applicable

Completed

• Conditions: Obesity; Weight Loss

• Registration Number: NCT00854412
• Lead Sponsor: University of Aarhus

Brief Summary

High levels of mannose-binding lectin (MBL), an activator of a part of the immune system called the complement system, have been associated with increased mortality and risk of early signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and changes in insulin resistance on MBL levels have been poorly elucidated.

This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet (VLCD) of 800 kcal/day for 8 weeks.

Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed using the HOMA-IR method.

Detailed Description

Not available

Study Timeline

• Study Start: 1995-03
• Primary Completion: 1995-06
• Study Completion: 1995-06
• Status Verified: 2009-03
• Study First Submitted: 2009-03-02
• Study First Submitted QC: 2009-03-02
• Last Update Submitted: 2009-03-02
• Study First Posted: 2009-03-03
• Last Update Posted: 2009-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Obese

Exclusion Criteria

• Diabetes
• Other severe disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP