Brain Reaction to Treatment of Nicotine Dependence

Phase 1

Completed

• Conditions: Nicotine Dependence
• Interventions: Drug: Zyban

• Registration Number: NCT00108173
• Lead Sponsor: US Department of Veterans Affairs

Brief Summary

The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Detailed Description

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Study Timeline

• Study Start: 2002-10
• Study First Submitted: 2005-04-14
• Study First Submitted QC: 2005-04-14
• Study First Posted: 2005-04-15
• Primary Completion: 2007-04
• Study Completion: 2011-06
• Status Verified: 2013-04
• Last Update Submitted: 2013-04-05
• Last Update Posted: 2013-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• Heavy smoker, more than one pack per day
• Free of medical conditions or medications that affect brain activity
• Not pregnant

Exclusion Criteria

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 1	Zyban	-

Primary Outcome Measures

Name	Time	Method
2-FA PET scan results	Within the first few weeks of study initiation	Brain activity and activation in response to cigarette-related cues

Trial Locations

Locations (1)

VA Greater Los Angeles Healthcare System, West LA; 🇺🇸 West Los Angeles, California, United States