The Antipyretic Efficacy of Oral and Intravenous Paracetamol and Intramuscular Diclofenac in Patients Presenting With Fever.

Not Applicable

Completed

• Conditions: Fever; Reduction in Temperature
• Interventions: Drug: Oral paracetamol; Drug: Intravenous paracetamol; Drug: Intramuscular diclofenac

• Registration Number: NCT01891435
• Lead Sponsor: Hamad Medical Corporation

Brief Summary

A randomized clinical trial to check the antipyretic efficacy of oral and intravenous paracetamol and intramuscular diclofenac sodium in patients presenting with fever to emergency department.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-12
• Study Completion: 2013-04
• Status Verified: 2013-06
• Study First Submitted: 2013-06-21
• Study First Submitted QC: 2013-06-28
• Last Update Submitted: 2013-06-28
• Study First Posted: 2013-07-03
• Last Update Posted: 2013-07-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 434

Inclusion Criteria

• Adults between the age of 14-75 years with an oral temperature of more than 38.5 C

Exclusion Criteria

• History of allergy to any of the drugs in the study
• Had taken antipyretics within 8 hours
• Renal, hepatic or haematological disorders
• bronchial asthma, peptic ulcer disease, vomiting
• Pregnant or lactating women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
oral paracetamol	Oral paracetamol	patients in this arm will receive 1000mg of oral paracetamol
Intravenous paracetamol	Intravenous paracetamol	patients in this arm will receive 1000 mg of intravenous paracetamol
Intramuscular Diclofenac	Intramuscular diclofenac	patients in this arm will receive 75 mg of intramuscular diclofenac sodium

Primary Outcome Measures

Name	Time	Method
Reduction in temperature in every thirty minutes till 120 minutes after receiving antipyretics	Reduction in temperature is checked every 30 minutes for a maximum of 120 minutes	Once the patients fulfill the inclusion criteria, they are randomly assigned to receive one of the three medications in the study ( oral paracetamol, intravenous paracetamol or intramuscular diclofenac). Baseline temperature is recorded using a standard thermometer. Then reduction in temperature is recorded every 30 minutes for 2 hours.

Trial Locations

Locations (1)

Hamad medical corporation; 🇶🇦 Doha, Qatar