Classical Monocyte Kinetics in Chronic Myelomonocytic Leukemia

Not Applicable

Completed

• Conditions: Myelomonocytic Leukemia
• Interventions: Other: Deuterium Glucose

• Registration Number: NCT04775121
• Lead Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Brief Summary

To measure the rate of bone marrow release and the lifespan of classical monocytes in the peripheral blood of patients with a chronic myelomonocytic leukemia

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-13
• Study First Submitted: 2021-02-23
• Study First Submitted QC: 2021-02-26
• Study First Posted: 2021-03-01
• Primary Completion: 2023-11-04
• Study Completion: 2023-11-04
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-23
• Last Update Posted: 2024-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experimental	Deuterium Glucose	Oral administration of 20 g Deuterium Glucose on a 3-hour period followed by sequential blood sampling to sort monocytes on a 30-days period of time
Healthy volunteers	Deuterium Glucose	Oral administration of 20 g Deuterium Glucose on a 3-hour period followed by sequential blood sampling to sort monocytes on a 30-days period of time

Primary Outcome Measures

Name	Time	Method
Bone marrow release	up to 30 days	To measure bone marrow release in the peripheral blood of patients with a chronic myelomonocytic leukemia and age-matched healthy volunteers

Trial Locations

Locations (2)

Gustave Roussy; 🇫🇷 Villejuif, Val De Marne, France

Hôpital Saint Louis; 🇫🇷 Paris, France