Intraoperative Conversion During Video-assisted Thoracoscopy Resection for Lung Cancer Does Not Alter Survival

Completed

• Conditions: Video-assisted Thoracoscopic Surgery; Lobectomy; Surgery; Survival; Lung Cancer
• Interventions: Procedure: anatomical resection

• Registration Number: NCT04663191
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Anatomical resection with systematic lymph-node dissection is currently the standard of care for the treatment of early stage non-small cell lung cancer. The use of minimally invasive approaches has increased greatly over the last two decades \[either video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS)\], as they provide the patient with better outcomes than open thoracotomy. Minimally invasive VATS lobectomy for a standard case is generally a straightforward procedure for a well-trained surgical team, although concomitant preoperative pathologies or intraoperative findings/adverse events may result in technical difficulties, leading to intraoperative conversion, commonly by thoracotomy.

The investigators aimed to assess long-term outcomes in a consecutive cohort of patients treated by anatomical pulmonary resection either using VATS, VATS requiring intraoperative conversion to thoracotomy, or upfront open thoracotomy for lung-cancer surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-02
• Status Verified: 2020-12
• Primary Completion: 2020-12-02
• Study Completion: 2020-12-03
• Study First Submitted: 2020-12-04
• Study First Submitted QC: 2020-12-04
• Study First Posted: 2020-12-10
• Last Update Submitted: 2020-12-11
• Last Update Posted: 2020-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 843

Inclusion Criteria

• All consecutive patients treated by anatomical lobar pulmonary resection (lobectomy, bilobectomy) or anatomical sublobar pulmonary resection (segmentectomy) for non-small cell lung cancer (NSCLC), either by VATS (eventually with intraoperative conversion) or upfront thoracotomy.

Exclusion Criteria

• patients with non-anatomical pulmonary resection (wedge resection)
• patients with a histology other than NSCLC (benign or metastatic from another primitive cancer), stage IV NSCLC disease,
• patients with multiple primary NSCLC (synchronous or metachronous)
• patients with incomplete resection (R+)
• patient for whom a VATS approach was never considered

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Full VATS	anatomical resection	-
VATS with conversion	anatomical resection	-
Thoracotomy upfront	anatomical resection	-

Primary Outcome Measures

Name	Time	Method
Overall survival during the follow-up period after surgery	from day of surgery up to 7 years

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France