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临床试验/NCT04663191
NCT04663191已完成不适用

Intraoperative Conversion During Video-assisted Thoracoscopy Resection for Lung Cancer Does Not Alter Survival

Centre Hospitalier Universitaire, Amiens1 个研究点 分布在 1 个国家目标入组 843 人开始时间: 2020年1月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
843
试验地点
1
主要终点
Overall survival during the follow-up period after surgery

研究概览

简要总结

Anatomical resection with systematic lymph-node dissection is currently the standard of care for the treatment of early stage non-small cell lung cancer. The use of minimally invasive approaches has increased greatly over the last two decades [either video-assisted thoracoscopic surgery (VATS) or robotic-assisted thoracoscopic surgery (RATS)], as they provide the patient with better outcomes than open thoracotomy. Minimally invasive VATS lobectomy for a standard case is generally a straightforward procedure for a well-trained surgical team, although concomitant preoperative pathologies or intraoperative findings/adverse events may result in technical difficulties, leading to intraoperative conversion, commonly by thoracotomy.

The investigators aimed to assess long-term outcomes in a consecutive cohort of patients treated by anatomical pulmonary resection either using VATS, VATS requiring intraoperative conversion to thoracotomy, or upfront open thoracotomy for lung-cancer surgery.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All consecutive patients treated by anatomical lobar pulmonary resection (lobectomy, bilobectomy) or anatomical sublobar pulmonary resection (segmentectomy) for non-small cell lung cancer (NSCLC), either by VATS (eventually with intraoperative conversion) or upfront thoracotomy.

排除标准

  • patients with non-anatomical pulmonary resection (wedge resection)
  • patients with a histology other than NSCLC (benign or metastatic from another primitive cancer), stage IV NSCLC disease,
  • patients with multiple primary NSCLC (synchronous or metachronous)
  • patients with incomplete resection (R+)
  • patient for whom a VATS approach was never considered

结局指标

主要结局

Overall survival during the follow-up period after surgery

时间窗: from day of surgery up to 7 years

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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