Hyperoxic Exercise in Type 2 Diabetes.
Recruiting
- Conditions
- Diabetes type 2
- Registration Number
- NL-OMON20199
- Lead Sponsor
- Erasmus MC, University Medical Center Rotterdam
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
1. Type 2 diabetes according to WHO criteria for over 2 years;
2. VO2peak 60-90% of age-predicted value as measured on a cycle-ergometer;
Exclusion Criteria
1. Use of Beta-blocker therapy, low molecular heparin, exogenous insulin therapy (for exercise intervention only),
use of oral anti-coagulans therapy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The relative improvement in whole-body insulin sensitivity. An insulin sensitivity index (SI) will be calculated by using<br>the minimal model (Bergman et al 1985); a higher SI indicates enhanced insulin sensitivity. Acute-phase insulin<br>secretion (AIRG) and glucose effectiveness (SG) were also determined from the IVGTT ( Bergman et al 1985).
- Secondary Outcome Measures
Name Time Method 1. Relative improvements in vascular function parameters using forearm plethysmography (change in forearmbloodflow in ml/100g forearm/min after nitriprusside/acetylcholine);<br /><br>2. Cardiovascular fitness (VO2max);<br /><br>3. Systemic blood pressure;<br /><br>4. Body composition;<br /><br>5. Lipid metabolism;<br /><br>6. Glycemic control. <br><br /><br /><br>In 12 subjects from the control group and 12 subjects from the intervention group: GLUT-4 expression in the muscle, mitochondrial enzymatic activity and muscle fiber morphologic characteristics from muscle biopsy analysis.