Comparision of an Intraoperative Infusion of Dexmedetomidine and Remifentanil on Intraoperative Hemodyanamic and Postoperative Recovery after Laproscopic Sterization- A Prospective Randamized Control Trial
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- to compare the intra operative hemodynamic parameters between dexmedetomidine
研究概览
简要总结
Remifentanil is an ultra-short-acting opioid and a favorable alternative to long-acting opioids during general anesthesia. It is 100 to 200 times more potent than morphine, with a short elimination half-life and context-sensitive half-life, leading to faster recovery with predictable offset. Dexmedetomidine is another commonly used non-opioid drug in anesthesia practice. It is a selective Alpha 2 Agonist having sedative, anxiolytic, hypnotic, analgesic and sympatholytic properties. Each of the drug has its own set of uses and side effects and has been increasingly used in perioperative clinical settings owing to their sedative and analgesic properties. we hypothesise that Dexmedetomidine provides more effective intra operative haemodyanamics compared to remifentanil in patients undergoing laparoscopic sterilization
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)(—)
- 性别
- Female
入选标准
- •1.American society of anesthesiologist physical status grade I, grade II 2.Patient undergoing laparoscopic sterilization.
排除标准
- •1.Patient refusal 2.Patients with severe cardiovascular, respiratory, renal, or hepatic diseases 3.known allergies or hypersensitivity to dexmedetomidine, remifentanil 4.Severe Obesity.
- •BMI 35-40 5.History of substance abuse or opioid dependency.
结局指标
主要结局
to compare the intra operative hemodynamic parameters between dexmedetomidine
时间窗: 0-60 minutes
and remifentanil group undergoing laparoscopic sterilization
时间窗: 0-60 minutes
次要结局
- To compare the recovery profile between dexmedetomidine and remifentanil group(using modified Aldrete score.)
- To compare the immediate post operative pain(Duration of post operative pain (dexmedetomidine/remifentanil)in minutes)
研究者
Mahesh kumar M
SRM medical college and research centre
