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临床试验/CTRI/2025/12/099959
CTRI/2025/12/099959尚未招募4 期

Comparision of an Intraoperative Infusion of Dexmedetomidine and Remifentanil on Intraoperative Hemodyanamic and Postoperative Recovery after Laproscopic Sterization- A Prospective Randamized Control Trial

SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE1 个研究点 分布在 1 个国家目标入组 84 人开始时间: 2026年1月22日最近更新:

试验速览

阶段
4 期
状态
尚未招募
入组人数
84
试验地点
1
主要终点
to compare the intra operative hemodynamic parameters between dexmedetomidine

研究概览

简要总结

Remifentanil is an ultra-short-acting opioid and a favorable alternative to long-acting opioids during general anesthesia. It is 100 to 200 times more potent than morphine, with a short elimination half-life and context-sensitive half-life, leading to faster recovery with predictable offset. Dexmedetomidine is another commonly used non-opioid drug in anesthesia practice. It is a selective Alpha 2 Agonist having sedative, anxiolytic, hypnotic, analgesic and sympatholytic properties. Each of the drug has its own set of uses and side effects and has been increasingly used in perioperative clinical settings owing to their sedative and analgesic properties. we hypothesise that Dexmedetomidine provides more effective intra operative haemodyanamics compared to remifentanil in patients undergoing laparoscopic sterilization

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
Participant and Investigator Blinded

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
Female

入选标准

  • 1.American society of anesthesiologist physical status grade I, grade II 2.Patient undergoing laparoscopic sterilization.

排除标准

  • 1.Patient refusal 2.Patients with severe cardiovascular, respiratory, renal, or hepatic diseases 3.known allergies or hypersensitivity to dexmedetomidine, remifentanil 4.Severe Obesity.
  • BMI 35-40 5.History of substance abuse or opioid dependency.

结局指标

主要结局

to compare the intra operative hemodynamic parameters between dexmedetomidine

时间窗: 0-60 minutes

and remifentanil group undergoing laparoscopic sterilization

时间窗: 0-60 minutes

次要结局

  • To compare the recovery profile between dexmedetomidine and remifentanil group(using modified Aldrete score.)
  • To compare the immediate post operative pain(Duration of post operative pain (dexmedetomidine/remifentanil)in minutes)

研究者

申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Mahesh kumar M

SRM medical college and research centre

研究点 (1)

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