ltrasound based parameters to decide discontinuation of ventilator support
- Conditions
- Health Condition 1: Z991- Dependence on respirator
- Registration Number
- CTRI/2023/05/052186
- Lead Sponsor
- PGIMER Dr RML Hospital New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
On invasive mechanical ventilation for more than 48 hours duration and put on spontaneous breathing trial (SBT) prior to extubation
1.Short-term mechanical ventilation ( <48 hours) in the early postoperative period
2.Refusal of consent
3.Patients with spinal cord injuries above the t8 level
4.Presence of significant cardiac arrhythmia
5.Patients with pre-existing diaphragmatic disorders
6.Patients with any neuromuscular weakness or ICU-acquired neuromyopathy
7.Planned non-invasive ventilation(NIV) following extubation
8.Chest or abdominal trauma
9.Patients with distorted abdominal wall anatomy or localized fluid collections in the abdomen, hernias, abdominal wall hematomas, inguinal masses, femoral hernias & abdominal surgeries
10.Pregnant patients
11.Poor ultrasound window
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Combination of lung ultrasound score (LUS), diaphragmatic thickening fraction (DTF), diaphragmatic excursion(DE), internal oblique thickening fraction and diaphragmatic rapid shallow breathing index(D-RSBI) in prediction of successful weaning and extubation failure.Timepoint: 120 minutes following successful spontaneous breathing trial
- Secondary Outcome Measures
Name Time Method 1. Estimate cut-off sensitivity and specificity of internal oblique thickening fraction and diaphragmatic RSBI to predict successful weaning. <br/ ><br>2. Compose a comprehensive score based upon ultrasound based weaning indices for prediction of successful weaning. <br/ ><br>Timepoint: 12 months