NL-OMON50261
Recruiting
Phase 4
Partial neuromuscular blockade to facilitate lung and diaphragm protective mechanical ventilation in ICU patients: A randomized controlled pilot study. - Partial neuromuscular blockade for lung protective mechanical ventilation
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Middenrif / longfunctie
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 30
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- high respiratory drive, defined as tidal volume \> 8ml/kg PBW on inspiratory
- •support of 12cmH2O.
- •\- sedation level: RASS \<\= \-3
- •\- ventilated in pressure support mode
Exclusion Criteria
- •\- recent use of NMBA (\<2 hrs)
- •\- arterial pH \<7\.25
- •\- hemodynamic instability, i.e. high dose vasopressors (\>0\.5 µg/kg/min) or
- •inotropes (dobutamine \>15 µg/kg/min or enoximone \>25 µg/kg/min)
- •\- intracranial pressure \>20 cmH2O
- •\- past medical history of neuromuscular disorders
- •\- pregnancy
- •\- known previous anaphylactic reaction to NMBA\*s.
Outcomes
Primary Outcomes
Not specified
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