EUCTR2018-000748-24-NL
Active, not recruiting
Phase 1
Partial neuromuscular blockade to facilitate lung and diaphragm protectivemechanical ventilation in ICU patients.A randomized controlled pilot study.
DrugsEsmeron
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- VUmc
- Enrollment
- 30
- Status
- Active, not recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients are eligible for inclusion if they meet all of the following
- •\- high respiratory drive, defined as tidal volume \> 8ml/kg PBW on
- •inspiratory support of 12cmH2O.
- •\- sedation level: RASS \= \-3
- •\- ventilated in pressure support mode
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 15
- •F.1\.3 Elderly (\>\=65 years) yes
Exclusion Criteria
- •A potential subject who meets any of the following criteria will be
- •excluded from participation in this study:
- •\- recent use of NMBA (\< 2 hrs)
- •\- arterial pH \< 7\.25
- •\- hemodynamic instability, i.e. high dose vasopressors (\>0\.5 µg/kg/min)
- •or inotropes (dobutamine \>15 µg/kg/min or enoximone \>25
- •\- intracranial pressure \> 20 cmH2O
- •\- past medical history of neuromuscular disorders
- •\- pregnancy
- •\- known previous anaphylactic reaction to NMBA's.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Phase 4
Partial neuromuscular blockade to facilitate lung and diaphragm protective mechanical ventilation in ICU patients: A randomized controlled pilot study.Middenrif / longfunctieDiaphragm dysfunctionlung injury due to mechanical ventilationNL-OMON50261Vrije Universiteit Medisch Centrum30
Unknown
Phase 4
Partial Neuromuscular Blockade for Lung Protective Mechanical VentilationRespiratory InsufficiencyNCT03646266Amsterdam UMC, location VUmc30
Active, not recruiting
Phase 1
Addition of neuromuscular-blocking agents during induction in infants: potential interest in reducing episodes of oxygen decrease in bloodEUCTR2015-001668-21-FRFondation Ophtalomologique A. de Rothschild412
Completed
Not Applicable
Effects of neuromuscular blockade on transpulmonary pressure and diaphragm activity in paediatric moderate-to-severe acute respiratory distress syndrome: a pilot studyPARDS10038716NL-OMON45389niversitair Medisch Centrum Groningen19
Recruiting
Not Applicable
Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory FailureNCT04524585University Health Network, Toronto23