The effect of prenatal administration of folic acid on maternal plasma homocysteine concentration and its relationship with the development of preeclampsia
Not Applicable
- Conditions
- preeclampsia.Gestational [pregnancy-induced] hypertension with significant proteinuria
- Registration Number
- IRCT201402175283N9
- Lead Sponsor
- ?Drug Applied Research Center, Tabriz University of Medical Sciences and Health Services
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 400
Inclusion Criteria
Healthy mothers with a singleton pregnancy aged between 20-30 years old Exclusion criteria: Heart disease; chronic hypertension; Diabetes mellitus; collagen vascular diseases; chronic renal disease; preterm delivery for the other reasons except preeclampsia; taking medications other than calcium and ferrous sulfate and vitamin B6.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decreasion in homocysteine level. Timepoint: first trimester and at delivery time. Method of measurement: serum sampeling.;Prevention of preeclampsia. Timepoint: after 20th week of pregnancy age. Method of measurement: controling of severe signs, body weight, blood pressure, edema, urine protein in every visit.
- Secondary Outcome Measures
Name Time Method Preterm labor. Timepoint: labor after 20-37. Method of measurement: clinical examination.;Prevention of IUGR. Timepoint: After 24 weeks every month. Method of measurement: sonography.