NCT01332136已完成不适用
Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 966
- 试验地点
- 1
- 主要终点
- Disease-specific quality of life
研究概览
简要总结
This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult (>= 18 years)
- •Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines
- •Able to complete all surveys/questionnaires in English
- •Persistent symptoms following initial medical management
- •Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days
- •Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy.
- •Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery
排除标准
- •Children (<18 years)
- •Unable to complete all surveys/questionnaires at baseline
结局指标
主要结局
Disease-specific quality of life
时间窗: 18 months post-treatment
次要结局
- Olfaction(18 months post-treatment)
- General health-related quality-of-life(18 months post-treatment)
研究者
Dr. Timothy L. Smith
Professor
Oregon Health and Science University
研究点 (1)
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