Determinants of Medical and Surgical Treatment Outcomes in Chronic Sinusitis
Completed
- Conditions
- Chronic Rhinosinusitis
- Registration Number
- NCT01332136
- Lead Sponsor
- Oregon Health and Science University
- Brief Summary
This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 966
Inclusion Criteria
- Adult (>= 18 years)
- Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines
- Able to complete all surveys/questionnaires in English
- Persistent symptoms following initial medical management
- Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days
- Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy.
- Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery
Exclusion Criteria
- Children (<18 years)
- Unable to complete all surveys/questionnaires at baseline
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disease-specific quality of life 18 months post-treatment
- Secondary Outcome Measures
Name Time Method Olfaction 18 months post-treatment General health-related quality-of-life 18 months post-treatment
Trial Locations
- Locations (1)
Oregon Health & Science University
đŸ‡ºđŸ‡¸Portland, Oregon, United States