NCT01149382已完成不适用
Humoral Immune Response To Influenza Vaccine In Islet Cell In Transplant Recipients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- •Seroprotection rate
研究概览
简要总结
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown that the standard inactivated influenza vaccine has poor immunogenicity in this population. The investigators plan to test the humoral response to vaccination and look at HLA upregulation
详细描述
OBJECTIVE AND HYPOTHESIS
- To test the specific humoral response of the influenza vaccine after islet cell transplantation
- To test the production of HLA alloantibodies after vaccination.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult islet cell transplant recipients
- •Able to provide informed consent
排除标准
- •Egg allergy
- •Previous life-threatening reaction to influenza vaccine (ie Guillain Barre Syndrome)
- •Febrile illness in the past two weeks
- •Unable to provide informed consent
结局指标
主要结局
•Seroprotection rate
时间窗: 3 months
defined as a post-vaccination titer of ≥1:40
次要结局
- •Seroconversion rate(3 months)
研究者
Deepali Kumar
Assistant Professor
University of Alberta
研究点 (1)
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