Comparison of effectiveness of two different doses of nebulised dexmedetomidine with lignocaine for awake fibreoptic intubation.

Phase 4

Not yet recruiting

• Registration Number: CTRI/2023/10/059186
• Lead Sponsor: Rabindranath Tagore Medical College

Brief Summary

Among the various methods to facilitate AFOI, topical anaesthesia with LA (lignocaine) nebulisation is a commonly used technique. However, topical anaesthesia with lignocaine alone may be inadequate in some patients.

Dexmedetomidine, a selective alpha- 2 adrenergic agonist, that provides both analgesia and sedation without causing respiratory depression.    Only two studies have been done where this combination (dexmedetomidine in a dose of 0.6 µg/kg  and 1 µg/kg)   has been   used for flexible fiberoptic bronchoscopy Till date.We hypothesised that combination of nebulised dexmedetomidine-lidocaine could reduce the incidence of moderate to severe coughing during AFOI

With more intubation comfort, better post-intubation tolerance and patient satisfaction along with adequate sedation and stable haemodynamics.The present study has been planned with an aim of comparing the effectiveness of two different doses of nebulised dexmedetomidine with lignocaine for AFOI in patients undergoing surgery under general anaesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-06-11
• Last Update Posted: 2023-10-26

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

2.Patients with American Society of Anesthesiologists (ASA) Physical Status (PS) I and II 3.Patients with Mallampati Class I and II.

Exclusion Criteria

• Patients who have not given consent.
• 2.Patients with age <18 and >50 years 3.
• Patients with ASA PS III and IV and Mallampati class III and IV 4.
• Patients with BMI >35 kg/m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cough severity score during awake fiber optic intubation	During awake fiber optic intubation (2 minutes)

Secondary Outcome Measures

Name	Time	Method
Intubation comfort score	Post intubation behavior score/Assessment

Trial Locations

Locations (1)

Maharana Bhupal Government Hospital Udaipur Rajasthan 313001; 🇮🇳 Udaipur, RAJASTHAN, India

Maharana Bhupal Government Hospital Udaipur Rajasthan 313001

🇮🇳Udaipur, RAJASTHAN, India

Dr abhay kumar lodhi

Principal investigator

7772832656

abhaykumarlodhi@gmail.com