Stratification in Alzheimer's disease

lster University0 个研究点目标入组 600 人开始时间: 2017年11月3日最近更新: 2020年7月27日

适应症

试验速览

暂无简介。

•Inclusion criteria for age of onset Alzheimer’s disease patients:
•1. Male and female participants
•2. Aged between 45-84
•3. Diagnosis of Alzheimer’s disease (50 aged 45-54, 50 aged 55-64, 50 aged 65-74, 50 aged 75-84)
•Inclusion criteria for ‘other dementia’ group in age of onset study:
•1. Male and female participants
•2. Aged between 45-84
•3. With an ‘other’ diagnosis of dementia (i.e. NOT Alzheimer’s disease) including but not limited to: Vascular Dementia (VaD), Frontotemporal dementia (FTD), Dementia with Lewy Bodies (DLB)
•Inclusion criteria for MCI group in age of onset study:
•1. Male and female participants
•2. Aged between 45-84
•3. A diagnosis of Mild Cognitive Impairment (MCI)
•Inclusion criteria for apparently healthy cohort in age of onset study:
•1. Men and women
•2. Aged between 45-84 (50 aged 45-54, 50 aged 55-64, 50 aged 65-74, 50 aged 75-84)
•Inclusion criteria for imaging sub study:
•1. Men and women
•2. Aged 45-84
•3. Diagnosis of MCI, Alzheimer’s disease, other dementia and healthy controls (25 per group)

•Exclusion criteria for all age of onset participants:
•Participants with a bleeding disorder, for which, blood sampling would not be advisable.
•Exclusion criteria for imaging sub study:
•1. Participants with a bleeding disorder, for which blood sampling would not be advisable
•2. Pregnancy
•3. Previous head or neck surgery
•4. Suffer from epilepsy or migraine
•5. Active implants (pacemaker, neurostimulator, insulin pump, ossicular prosthesis)
•6. May have metal fragments in the body
•7. Have jewellery/piercings that cannot be removed
•8. Suffer from claustrophobia

发起方

lster University