NCT01428323Unknown不适用
Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets
Cliniques universitaires Saint-Luc- Université Catholique de Louvain2 个研究点 分布在 1 个国家目标入组 7 人开始时间: 2011年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 7
- 试验地点
- 2
- 主要终点
- Amikacin Urinatory excretion
研究概览
简要总结
Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear.
Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy Volunteers between 18 and 60 years old
排除标准
- •Pathological spirometry
- •History of treatment with aminoglygosides 1 month prior the study
- •Known allergy to aminoglycosydes
- •Any lung pathology or history of lung surgery
结局指标
主要结局
Amikacin Urinatory excretion
时间窗: Each miction during 24 hours
次要结局
未报告次要终点
研究者
研究点 (2)
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