Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation
Overview
- Phase
- Not Applicable
- Intervention
- technetium-99m - Diethylenetriaminepentaacetic acid
- Conditions
- Post-operative Neurosurgery
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Pulmonary deposition
- Status
- Terminated
- Last Updated
- 8 years ago
Overview
Brief Summary
Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used.
The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Invasive mechanical ventilation
- •Healthy lungs
Exclusion Criteria
- •Discontinued procedure due to adverse events.
Arms & Interventions
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
Intervention: technetium-99m - Diethylenetriaminepentaacetic acid
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
Intervention: Vibrating-mesh nebulizer
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
Intervention: Planar scintigraphy
Nebulization with a vibrating-mesh nebulizer
Nebulization performed with a vibrating-mesh nebulizer
Intervention: Preoperative spirometry
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
Intervention: technetium-99m - Diethylenetriaminepentaacetic acid
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
Intervention: Jet Nebulizer
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
Intervention: Planar scintigraphy
Nebulization with a jet nebulizer
Nebulization performed with a jet nebulizer
Intervention: Preoperative spirometry
Outcomes
Primary Outcomes
Pulmonary deposition
Time Frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes
Secondary Outcomes
- Penetration index(Immediately after nebulization by imaging assessment, an expected average of 30 minutes)
- Lung function(Preoperative assessment, the day before inclusion)
- Mechanical ventilation settings(During nebulisation time, an expected average of 15 minutes)