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临床试验/NCT02429817
NCT02429817已完成不适用

Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Cliniques universitaires Saint-Luc- Université Catholique de Louvain1 个研究点 分布在 1 个国家目标入组 6 人开始时间: 2015年4月最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
6
试验地点
1
主要终点
Pulmonary deposition

研究概览

简要总结

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.

On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.

Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
盲法
Double (Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • Healthy respiratory function

排除标准

  • Pulmonary disease

研究组 & 干预措施

Aeroneb Solo

Active Comparator

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.

干预措施: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)

Aeroneb Solo

Active Comparator

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.

干预措施: Aeroneb Solo (Device)

Aeroneb Solo

Active Comparator

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.

干预措施: Single photon emission computed tomography (Other)

Aeroneb Solo

Active Comparator

Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.

干预措施: Spirometry (Other)

Standard Jet Nebulizer

Active Comparator

Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

干预措施: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)

Standard Jet Nebulizer

Active Comparator

Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

干预措施: Jet Nebulizer (Device)

Standard Jet Nebulizer

Active Comparator

Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

干预措施: Single photon emission computed tomography (Other)

Standard Jet Nebulizer

Active Comparator

Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

干预措施: Spirometry (Other)

结局指标

主要结局

Pulmonary deposition

时间窗: Immediately after nebulization by imaging technique, expected average of 15 minutes

Single photon emission tomography combined with a CT-scan

次要结局

  • Three-dimensional penetration index(immediately after the nebulization by imaging assessment, expected average of 30 minutes)

研究者

发起方
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
申办方类型
Other
责任方
Sponsor

研究点 (1)

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