Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula
Overview
- Phase
- Not Applicable
- Intervention
- Technetium-99m - Diethylenetriaminepentaacetic acid
- Conditions
- Healthy
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Pulmonary deposition
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.
On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.
Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy respiratory function
Exclusion Criteria
- •Pulmonary disease
Arms & Interventions
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Technetium-99m - Diethylenetriaminepentaacetic acid
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Aeroneb Solo
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Single photon emission computed tomography
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Spirometry
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Technetium-99m - Diethylenetriaminepentaacetic acid
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Jet Nebulizer
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Single photon emission computed tomography
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Spirometry
Outcomes
Primary Outcomes
Pulmonary deposition
Time Frame: Immediately after nebulization by imaging technique, expected average of 15 minutes
Single photon emission tomography combined with a CT-scan
Secondary Outcomes
- Three-dimensional penetration index(immediately after the nebulization by imaging assessment, expected average of 30 minutes)