Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Pulmonary deposition
研究概览
简要总结
Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.
On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.
Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy respiratory function
排除标准
- •Pulmonary disease
研究组 & 干预措施
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
干预措施: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
干预措施: Aeroneb Solo (Device)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
干预措施: Single photon emission computed tomography (Other)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
干预措施: Spirometry (Other)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
干预措施: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
干预措施: Jet Nebulizer (Device)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
干预措施: Single photon emission computed tomography (Other)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
干预措施: Spirometry (Other)
结局指标
主要结局
Pulmonary deposition
时间窗: Immediately after nebulization by imaging technique, expected average of 15 minutes
Single photon emission tomography combined with a CT-scan
次要结局
- Three-dimensional penetration index(immediately after the nebulization by imaging assessment, expected average of 30 minutes)