Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 6
- Locations
- 1
- Primary Endpoint
- Pulmonary deposition
Study Overview
Brief Summary
Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.
On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.
Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Masking
- Double (Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy respiratory function
Exclusion Criteria
- •Pulmonary disease
Arms & Interventions
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Aeroneb Solo (Device)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Single photon emission computed tomography (Other)
Aeroneb Solo
Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Intervention: Spirometry (Other)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Jet Nebulizer (Device)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Single photon emission computed tomography (Other)
Standard Jet Nebulizer
Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Intervention: Spirometry (Other)
Outcomes
Primary Outcomes
Pulmonary deposition
Time Frame: Immediately after nebulization by imaging technique, expected average of 15 minutes
Single photon emission tomography combined with a CT-scan
Secondary Outcomes
- Three-dimensional penetration index(immediately after the nebulization by imaging assessment, expected average of 30 minutes)