Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: Technetium-99m - Diethylenetriaminepentaacetic acid; Device: Aeroneb Solo; Device: Jet Nebulizer; Other: Single photon emission computed tomography; Other: Spirometry

• Registration Number: NCT02429817
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.

On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer.

Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-04-20
• Study First Submitted QC: 2015-04-24
• Study First Posted: 2015-04-29
• Status Verified: 2016-12
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Last Update Submitted: 2016-12-02
• Last Update Posted: 2016-12-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 6

Inclusion Criteria

• Healthy respiratory function

Exclusion Criteria

• Pulmonary disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Aeroneb Solo	Technetium-99m - Diethylenetriaminepentaacetic acid	Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Standard Jet Nebulizer	Technetium-99m - Diethylenetriaminepentaacetic acid	Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Aeroneb Solo	Aeroneb Solo	Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Standard Jet Nebulizer	Jet Nebulizer	Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Standard Jet Nebulizer	Single photon emission computed tomography	Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.
Aeroneb Solo	Single photon emission computed tomography	Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Aeroneb Solo	Spirometry	Subjects inhaled radiolabelled aerosol via the Aeroneb Solo connected to the high flow nasal cannula.
Standard Jet Nebulizer	Spirometry	Subjects inhaled radiolabelled aerosol via the jet nebulizer connected to the high flow nasal cannula.

Primary Outcome Measures

Name	Time	Method
Pulmonary deposition	Immediately after nebulization by imaging technique, expected average of 15 minutes	Single photon emission tomography combined with a CT-scan

Secondary Outcome Measures

Name	Time	Method
Three-dimensional penetration index	immediately after the nebulization by imaging assessment, expected average of 30 minutes

Trial Locations

Locations (1)

Cliniques Universitaires Saint-Luc; 🇧🇪 Brussels, Belgium