Evaluation of Aerosol Delivery in Different Types of Nebulizers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Asthma
- Sponsor
- Chang Gung University
- Enrollment
- 10
- Primary Endpoint
- Inhaled and exhaled drug concentrations
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults.
Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.
Detailed Description
Material and Methods The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers: 1. a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan); 2. a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany); 3. a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and 4. a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.
Investigators
Hui-Ling Lin
Assistant professor
Chang Gung University
Eligibility Criteria
Inclusion Criteria
- •Healthy college subjects
Exclusion Criteria
- •Currently smoker
- •History of asthma
- •Drug allergy
- •Pulmonary disease
- •Heart disease
- •Arrythmia
- •Hyperthyroids
- •Diabetes mellitus
- •Lactacidosis
- •Under B-blocker medications
Outcomes
Primary Outcomes
Inhaled and exhaled drug concentrations
Time Frame: Drug deposition was tested Immediately after each nebulization, expected average of 20 minutes
Drug deposited on the collecting filter was analyzed.
Secondary Outcomes
- Breathing parameters(During each nebulization testing, an expected average of 10 minutes)