Evaluation of Aerosol Delivery in Different Types of Nebulizers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- Inhaled and exhaled drug concentrations
研究概览
简要总结
Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults.
Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.
详细描述
Material and Methods
The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers:
- a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan);
- a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany);
- a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and
- a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 25 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy college subjects
排除标准
- •Currently smoker
- •History of asthma
- •Drug allergy
- •Pulmonary disease
- •Heart disease
- •Arrythmia
- •Hyperthyroids
- •Diabetes mellitus
- •Lactacidosis
- •Under B-blocker medications
结局指标
主要结局
Inhaled and exhaled drug concentrations
时间窗: Drug deposition was tested Immediately after each nebulization, expected average of 20 minutes
Drug deposited on the collecting filter was analyzed.
次要结局
- Breathing parameters(During each nebulization testing, an expected average of 10 minutes)
研究者
Hui-Ling Lin
Assistant professor
Chang Gung University