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Clinical Trials/NCT01428323
NCT01428323
Unknown
Not Applicable

Study of the Aerosol Deposition With Vented and Unvented Jet Nebulizer in Healthy Subjets

Cliniques universitaires Saint-Luc- Université Catholique de Louvain1 site in 1 country7 target enrollmentJanuary 2011
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ConditionsAerosol Drug Therapy

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Aerosol Drug Therapy
Sponsor
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Enrollment
7
Locations
1
Primary Endpoint
Amikacin Urinatory excretion
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Open-vent jet nebulizers are frequently used to promote drug lung deposition but their clinical efficacy and indications are not clear.

Our study aimed to compare inhaled mass, and lung deposition of amikacin by using a jet nebulizer (Sidestream) under two different configurations: vented and unvented coupled to a 110 ml corrugated piece of tubing.

Registry
clinicaltrials.gov
Start Date
January 2011
End Date
September 2011
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Male

Investigators

Sponsor
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Healthy Volunteers between 18 and 60 years old

Exclusion Criteria

  • •Pathological spirometry
  • •History of treatment with aminoglygosides 1 month prior the study
  • •Known allergy to aminoglycosydes
  • •Any lung pathology or history of lung surgery

Outcomes

Primary Outcomes

Amikacin Urinatory excretion

Time Frame: Each miction during 24 hours

Study Sites (1)

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