Evaluation of Aerosolized Drugs Deposition Delivered Through a Mechanical Ventilator
Overview
- Phase
- Not Applicable
- Intervention
- Salbutamol
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Chang Gung University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Inhaled drug dose
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. The objective of this study was to evaluate inhaled bronchodilator and mucolytic agents delivered through a ventilator system.
Detailed Description
Aerosolized medication is used widely to patients with respiratory illness and admitted in the intensive care unit, and includes bronchodilators, steroids, mucolytics, and antibiotics. Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. Only few clinical trials on aerosol delivery deposition were published in the last decades. In addition, inhaled bronchodilators, mucolytics, antibiotics, and steroids are often administered to ventilated patients in the intensive care units in Taiwan, but they are never studied. Therefore, the aim of this study was to evaluate inhaled bronchodilator and mucolytics (acetylcystine) delivered by a jet nebulizer through a ventilator system to intubated patients.
Investigators
Hui-Ling Lin
Assistant professor
Chang Gung University
Eligibility Criteria
Inclusion Criteria
- •Mechanical ventilated patients with an endotracheal tube intubated
- •Receiving aerosol therapy with salbutamol or acetylcystine
- •On relatively stable medical condition
Exclusion Criteria
- •Unstable hemodynamic status (e.g. blood pressure \<100/60 mmHg, under Intra-aortic balloon pump)
- •Infected with airborne pathogens (e.g. tuberculosis or Influenza virus)
- •Poor oxygenation (fraction of inspiratory oxygen \>0.8, under high frequency oscillatory ventilation, or extracorporeal membrane oxygenation)
Arms & Interventions
Drug depositions
Aerosol drug deposited delivered on the inhaled and exhaled filters and protective filters were evaluated. Salbutamol and Acetylcysteine were delivered by a jet nebulizer through a mechanical ventilator.
Intervention: Salbutamol
Drug depositions
Aerosol drug deposited delivered on the inhaled and exhaled filters and protective filters were evaluated. Salbutamol and Acetylcysteine were delivered by a jet nebulizer through a mechanical ventilator.
Intervention: Acetylcysteine
Outcomes
Primary Outcomes
Inhaled drug dose
Time Frame: Inhaled drug dose was collected Immediately after each nebulization, expected average of 20 minutes
Drug depositions in inspiratory filters were analyzed by a spectrophotometer.
Secondary Outcomes
- exhaled drug dose(Exhaled drug dose was collected Immediately after each nebulization, expected average of 20 minutes)