Analysis of the Distribution of Pulmonary Ventilation After Nebulization by Heliox Associated With Positive Expiratory Pressure in Patients Asthmatics Stable.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Distribution of volumes of the rib cage in asthma patients-Plesthysmography opto - electronic (POE).
研究概览
简要总结
Objective: To assess the influence of nebulization with bronchodilators carried by the heliox coupled to PEP in the distribution of compartimental lung volumes in asmathic adults and to correlate with pulmonary function data. Methods: A controlled randomized trial involving 27 patients divided into four groups: heliox + PEP, oxygen + PEP, heliox and oxygen. After the initial evaluation, it was placing 89 reflective markers attached to the surface of the trunk and images acquired by optoelectronic plethysmography (OEP) of six cameras. Three slow vital capacity maneuvers and quiet breathing regarded as phase control. After the control phase, all patients underwent nebulization with a distribution noninvasive system, semi-closed using 10 drops of Fenoterol Bromide and 20 drops of Ipratropium.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The study included individuals diagnosed with moderate to severe asthma with forced expiratory volume in one second (FEV1) <60% or FEV1 <60% - 80% predicted;
- •showing reversibility of bronchial obstruction after administration of bronchodilators at least 10% in FEV1.
排除标准
- •unable to understand or perform the spirometric maneuver;
- •with a history of smoking;
- •pulmonary comorbidities as chronic obstructive pulmonary disease (COPD);
- •bronchiectasis and tuberculosis sequel;
- •hemodynamic instability defined as heart rate (HR) greater than 150 bpm or systolic blood pressure below 90 mmHg or greater than 150mmHg;
- •pregnancy and any contraindication to the use of PEEP;
- •such as increased work of breathing (acute asthma);
- •active hemoptysis;
- •acute sinusitis;
- •pneumothorax;
- •untreated; surgery or facial trauma;
- •oral or injury;
- •epistaxis;
- •nausea and esophageal surgery.
结局指标
主要结局
Distribution of volumes of the rib cage in asthma patients-Plesthysmography opto - electronic (POE).
时间窗: 5 months
The markers are meant to reflect the infrared signal emitted by the POE to the sensors, which transform these signals into information about the movement of the chest. In this evaluation method the chest is considered a geometric model divided into three regions - the volume of pulmonary rib cage (Vrp), abdominal rib cage volume (Vra), part of the chest corresponding to the diaphragm, and abdomen (Va), and the overall volume of the chest (Vcw) the total volume of compartments.
次要结局
- Lung function in asthmatic subjects(5 mothns)
研究者
Daniella Cunha Brandao
PhD
Universidade Federal de Pernambuco