Plethysmography Opto-electronic and Asthma

Not Applicable

Completed

• Conditions: Asthma
• Interventions: Other: Heliox; Other: Oxygen; Other: PEEP

• Registration Number: NCT01784146
• Lead Sponsor: Universidade Federal de Pernambuco

Brief Summary

Objective: To assess the influence of nebulization with bronchodilators carried by the heliox coupled to PEP in the distribution of compartimental lung volumes in asmathic adults and to correlate with pulmonary function data. Methods: A controlled randomized trial involving 27 patients divided into four groups: heliox + PEP, oxygen + PEP, heliox and oxygen. After the initial evaluation, it was placing 89 reflective markers attached to the surface of the trunk and images acquired by optoelectronic plethysmography (OEP) of six cameras. Three slow vital capacity maneuvers and quiet breathing regarded as phase control. After the control phase, all patients underwent nebulization with a distribution noninvasive system, semi-closed using 10 drops of Fenoterol Bromide and 20 drops of Ipratropium.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Primary Completion: 2009-06
• Study Completion: 2009-11
• Status Verified: 2012-12
• Study First Submitted: 2013-01-30
• Study First Submitted QC: 2013-02-01
• Last Update Submitted: 2013-02-01
• Study First Posted: 2013-02-05
• Last Update Posted: 2013-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• The study included individuals diagnosed with moderate to severe asthma with forced expiratory volume in one second (FEV1) <60% or FEV1 <60% - 80% predicted;
• showing reversibility of bronchial obstruction after administration of bronchodilators at least 10% in FEV1.

Exclusion Criteria

• unable to understand or perform the spirometric maneuver;
• with a history of smoking;
• pulmonary comorbidities as chronic obstructive pulmonary disease (COPD);
• bronchiectasis and tuberculosis sequel;
• hemodynamic instability defined as heart rate (HR) greater than 150 bpm or systolic blood pressure below 90 mmHg or greater than 150mmHg;
• pregnancy and any contraindication to the use of PEEP;
• such as increased work of breathing (acute asthma);
• active hemoptysis;
• acute sinusitis;
• pneumothorax;
• untreated; surgery or facial trauma;
• oral or injury;
• epistaxis;
• nausea and esophageal surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PEEP + Heliox	Heliox	-
Oxygen + PEEP	PEEP	-
Oxygen	Oxygen	-
PEEP + Heliox	PEEP	-
Oxygen + PEEP	Oxygen	-
Heliox	Heliox	-

Primary Outcome Measures

Name	Time	Method
Distribution of volumes of the rib cage in asthma patients-Plesthysmography opto - electronic (POE).	5 months	The markers are meant to reflect the infrared signal emitted by the POE to the sensors, which transform these signals into information about the movement of the chest. In this evaluation method the chest is considered a geometric model divided into three regions - the volume of pulmonary rib cage (Vrp), abdominal rib cage volume (Vra), part of the chest corresponding to the diaphragm, and abdomen (Va), and the overall volume of the chest (Vcw) the total volume of compartments.

Secondary Outcome Measures

Name	Time	Method
Lung function in asthmatic subjects	5 mothns	In spirometry values were obtained for FEV1, PEF and forced vital capacity (FVC), considering the record as the best value according to the American Thoracic Society 18 the percentage of the predicted 16. For IC, we performed a correction of the weight. The present study included all patients were instructed to discontinue their medication twelve hours before the experiment as corticosteroids and bronchodilators for short or long duration for performing spirometry

Trial Locations

Locations (1)

Laboratório de Fisiologia e Fisioterapia cardiorespiratória; 🇧🇷 Recife, Pernambuco, Brazil