Incidence and Spectrum of Acute Kidney Injury in Cirrhotics and Assessment of New Biomarkers as Early Predictors of Acute Kidney Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- The incidence , spectrum and natural history of Acute Kidney Injury in patients with cirrhosis
研究概览
简要总结
500 patients with normal renal function will be prospectively studied and incidence, spectrum and natural history of AKI (Acute Kidney Injury) will be observed in them and in 200 patients with abnormal renal function fulfilling AKI (Acute Kidney Injury) criteria will be prospectively studied for 1 year. Also biomarkers will be studied and validated as early predictors of AKI (Acute Kidney Injury).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Group A: 500 patients of cirrhosis with normal baseline renal function will be enrolled Group B : 200 patients who present with AKI (Acute Kidney Injury) will be enrolled
排除标准
- •Age < 18 or > 70 years
- •Preexisting Chronic Renal Disease
- •Patients with obstructive uropathy.
- •Cirrhosis with HCC (HepatoCellular Carcinoma).
- •Advanced cardiopulmonary disease
- •Pregnancy
- •Patients with extrahepatic malignancy
结局指标
主要结局
The incidence , spectrum and natural history of Acute Kidney Injury in patients with cirrhosis
时间窗: 1 Year
Incidence is defined as No. of AKI (Acute Kidney Injury) patients during the follow up period of 1 year. Spectrum is defined as Grading of AKIN (Acute Kidney Injury Network) 1,2,3 in different child status (Child A,Child B and Child C) at the end . Natural History is defined as Occurrence of AKI (Acute Kidney Injury) and its recovery during the follow up period of 1 year.
次要结局
- To study predictive value of Cystatin C to determine progression or resolution of Acute Kidney Injury(1 Years)
- To study predictive value of Cystatin C in comparison to serum creatinine as early predictor of development and outcome of AKI in a cohort of Cirrhotics.(1 Years)