Comparing auto-titrating continuous positive airway pressure device with fixed continuous positive airway pressure device in improvement in hypercapnia among patients with obesity hypoventilation syndrome

Not Applicable

Recruiting

• Conditions: Obesity Hypoventilation Syndrome; Sleep Apnoea; Respiratory - Sleep apnoea; Diet and Nutrition - Obesity

• Registration Number: ACTRN12618000379213
• Lead Sponsor: Yizhong Zheng

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-03-14
• Last Update Posted: 21 July 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

•BMI>30kg.m-2
•Daytime respiratory failure with a PaCO2>45mmHg (OHS group)
•pH is in the normal range at admission (7.35-7.45)
•Treatment naïve of long-term positive airway pressure device i.e. the patient has not been using CPAP in the past 12 months.
•AHI>/= 30 events per hour

Exclusion Criteria

•Presence of any other condition that may contribute to hypoventilation including neuromuscular disease, chest wall abnormalities, respiratory depressant medications, COPD or an FEV1/FVC ratio of <0.7
•Uncontrolled medical or psychiatric conditions
•Any pre-existing heart failure with reduced ejection fraction
•Any pre-existing CVA/TIA
•Decompensated right heart failure
•Not proficient in English
•Inability to provide informed consent
•PaCO2 >60mmHg

Study & Design

• Study Type: Interventional
• Study Design: Not specified