Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents
- Conditions
- Endocrine System Diseases
- Interventions
- Dietary Supplement: test meal (500 kcal)
- Registration Number
- NCT02020395
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
- Detailed Description
The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- caucasian youth
- pubertal Tanner stage x, y, or z
- fasting plasma glucose > 7.0 mmol/L
- significant illness
- taking medications
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Test meal (500 kcal)_normal weight test meal (500 kcal) ham sandwich chocolate cream orange juice Test meal (500 kcal)_obese weight test meal (500 kcal) ham sandwich chocolate cream orange juice
- Primary Outcome Measures
Name Time Method Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents 2 hours blood sampling Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents
- Secondary Outcome Measures
Name Time Method Association between gastrointestinal peptides and insulin release 2 hours blood sampling Dynamics of gastrointestinal peptide secretion including Tmax and Cmax
Trial Locations
- Locations (1)
University Hospital Basel, Division of Gastroenterology and Hepatology
🇨ðŸ‡Basel, Switzerland